Hamels, who hasn't pitched since spraining his left ankle Tuesday against Washington, will throw a final bullpen session Tuesday before the Phillies finish a two-game series against the Cardinals.
"He's just getting his work in," said manager Charlie Manuel. "We definitely expect him to be ready Friday."
It's been a rough start to the season for the Phillies' ace, who has battled a series of nagging injuries since missing his Opening Day start on April 5 with inflammation in his left elbow.
Hamels is 0-2 with a 7.27 ERA in four starts, giving up 27 hits and five home runs in 17 1/3 innings.
B.J. Rains is an associate reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.