He made his first start on April 26, 1995, at Three Rivers Stadium in Pittsburgh. Baseball had just returned from a strike that forced the cancellation of the previous year's World Series and a delayed start to the season.
Upset fans weren't exactly thrilled to see Lieber, who recalled intense booing.
"They littered the field with bats, and I hit the next guy, Moises Alou, right in the back," Lieber said. "It was interesting."
Thought it's just a coincidence, 1995 was the worst healthy season of Lieber's career, and included a two-month demotion to Triple-A. He has since recovered to put together a career worthy of Opening Day starts.
No. 7 will be the second time he's started the game in the same city, as the game was in Philadelphia last season. Others were Pittsburgh, San Francisco, Chicago, Cincinnati and Tokyo.
Lieber pitched well in that March 29, 2000, game in Tokyo against the Mets -- the first time Major League Baseball opened a season outside North America -- and evolved as a staff ace.
"That was exciting," said Lieber said of starting in Tokyo, though he wasn't crazy about the pitching mound. "I never experienced anything like it."
St. Louis counters with Cy Young Award winner Chris Carpenter, who's coming off the best season of his career and having a brilliant spring. Despite being home, the Phillies likely won't score many runs.
This, nor the magnitude of Opening Day, will faze Lieber.
"The whole thing about it is, it's the first game and that's it," he said. "That's the way I look at it. It's great to kick off the season, but after that, you move on to the next game."
Phillies probable lineup|
RHP Chris Carpenter
21-5, 2.83 ERA in 2005
1-1, 10.61 ERA in 2005 vs. PHI
3-2, 5.56 ERA lifetime vs. PHI
RHP Jon Lieber
17-13, 4.20 ERA in 2005
1-1, 6.00 ERA in 2005 vs. STL
12-7, 4.67 ERA lifetime vs. STL
On the Internet
KYW CBS 3
WPHT 1210 AM
KTRS 550 AM
Wednesday: vs. St. Louis, 7:05 p.m. ET
Thursday: vs. St. Louis, 3:05 p.m. ET
Friday: vs. Los Angeles, 7:05 p.m. ET