The cheers turned into an even louder roar when Brown laced a 1-1 slider from D-backs right-hander Edwin Jackson off the scoreboard in right field for a double, scoring Jayson Werth.
Brown slid into second, popped up and tipped his helmet to the crowd.
"I wasn't expecting that," Brown said of the ovation. "I wasn't thinking about that at all. That was great, though."
Brown, who started in right field and hit sixth, finished 2-for-3 with an RBI double, two runs scored and a sacrifice fly in the Phillies' 7-1 victory, their seventh straight win and 10th in a row at home.
He also displayed some incredible speed when he scored from first on a double by Carlos Ruiz in the sixth.
"It was a lot of fun," Brown said. "I'm going to try and come back and do the same thing tomorrow. My nerves are there before every game. I was just trying to have fun."
Brown got his shot after center fielder Shane Victorino was placed on the 15-day disabled list with a strained left abdominal muscle Wednesday. Victorino suffered the injury diving back to first base in the sixth inning of Tuesday's 9-5 victory over the D-backs.
Brown hit a combined .327 with 20 home runs and 68 RBIs in 93 games this season with Double-A Reading and Triple-A Lehigh Valley.
"He's an exciting player," manager Charlie Manuel said. "He's got tools. He's got quite a bit of ability."
Brown was recently named the top prospect in baseball by Baseball America. He is also the only Minor League player the Phillies wouldn't trade in the past year, when they sent four prospects to the Indians for Cliff Lee and three more prospects to the Blue Jays for Roy Halladay.
Coincidentally, Brown was playing behind Halladay on Wednesday.
"I'm glad they didn't trade him," said Halladay. "He's going to be a good player. To come in, especially to a place like this with the expectations, fans, media and come in and produce on the first day, that has got to be a good feeling for him. He deserves a lot of credit."
After a whirlwind day like this, Brown was all smiles in the Phillies' clubhouse after the game.
"I'm very happy for him," left fielder Raul Ibanez said. "I think he's got a lot of ability and he showed the type of character that he has. He's a good player and a really good kid. I think with his talent and his character, he's going to get better and better. It's exciting for us to have him join our club."
Brown understands the challenge that awaits for the remainder of the season. He won't get too excited about one game.
But it was a heck of a start.
"It flew by," Brown said. "I'm just trying to take it all in and come back to do it the next day. I'm trying to keep my mind focused."
Andy Jasner is a contributor to MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.